Adherens Junctions: Demonstration in Human Epidermis
نویسندگان
چکیده
منابع مشابه
Adherens junctions
How did genetic analysis get started in this system? Here we depended on a breakthrough from the lab of Peter Wolk and Jeff Elhai at Michigan State. They showed that DNA could be transferred by conjugation from E. coli to Anabaena. Postdoc Bill Buikema first isolated mutants incapable of fixing nitrogen, most of which could not differentiate heterocysts. He then used a cosmid library of wild-ty...
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JCB • VOLUME 172 • NUMBER 1 • 2006 4 Virtual adherens junctions he textbook model of adherens junctions has been exploded, or severed, by Bill Weis, Soichiro Yamada, Frauke Drees, Sabine Pokutta, and W. James Nelson (Stanford University School of Medicine, Stanford, CA). There is no direct link, they say, between cadherin, via and -catenin, to actin. Weis’s original goal was ambitious—a structu...
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pithelial cells zipper together thanks to linear actin cables—cables that assemble at newly formed adherens junctions to stabilize them, thereby counteracting retractive forces at sites of cell–cell contact. Now, Agnieszka Kobielak, Amalia Pasolli, and Elaine Fuchs (Rockefeller University, New York, NY) have found that formin-1 drives the actin polymerization that creates the cables. Formin-1 e...
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The early 1980s brought a new focus to cell adhesion research. This field, which was dominated by structural characterization of different adhesion sites, their subcellular distribution and cytoskeletal association, became increasingly molecular. The adhesion receptors mediating the different forms of cell–matrix and cell–cell adhesion in a wide variety of cells were identified and their mode o...
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We describe here the subcellular distributions of three junctional proteins in different adherens-type contacts. The proteins examined include vinculin, talin, and a recently described 135-kD protein (Volk, T., and B. Geiger, 1984, EMBO (Eur. Mol. Biol. Organ.) J., 10:2249-2260). Immunofluorescent localization of the three proteins indicated that while vinculin was ubiquitously present in all a...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1993
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12462801